CD34+ engraftment

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Immunodeficient mice engrafted with functional human cells and tissues have become increasingly important as pre-clinical animal models for the study of human diseases.

  • L2P Research® offers CD34+ hematopoietic stem cell-engraftment service, these mice can develop multi-lineage human immune cells. < We Perform In-House verification by FACS to assess Engraftment >
  • We offer Hu-PBL-SCID, created by injection of human peripheral blood leukocytes. This model results in rapid engraftment of human CD3+ T cells. This model is excellent for studying human T cell function.
  • We offer Hu-SRC-SCID, encompasses the intravenous (IV) or intrafemoral injection of human SCID repopulating cells, i.e., human CD34+ HSCs derived from bone marrow (BM), umbilical cord blood (UBC), fetal liver or G-CSF-mobilized peripheral blood. This model supports engraftment of a complete human immune system.
  • We also offer bone marrow/liver/thymus “BLT” model that is established by transplantation of human fetal liver and thymus under the kidney capsule and IV injection of autologous fetal liver HSCs.

     - 12- 14 WEEKS (Wait Time)
     - Validate Presence of >25-30% huCD45 + cells 
     - Use the Animals for Your Research Study

   * Please  Contact Us to discuss generation of CD34+ engrafted mouse for your studies